radiosynthesis of [103pd]-di-actyl-bis (n4-methylthiosemicarbazone): a potential therapeutic agent

نویسندگان

a.r. jalilian department of cyclotron and nuclear medicine, nuclear research center for agriculture and medicine (nrcam), atomic organization of iran, karaj, iran

m. sadeghi department of cyclotron and nuclear medicine, nuclear research center for agriculture and medicine (nrcam), atomic organization of iran, karaj, iran

y.y. kamrani department of cyclotron and nuclear medicine, nuclear research center for agriculture and medicine (nrcam), atomic organization of iran, karaj, iran

a. bahrami department of cyclotron and nuclear medicine, nuclear research center for agriculture and medicine (nrcam), atomic organization of iran, karaj, iran

چکیده

background: due to interesting tumor imaging properties of bis-thiosemicarbazones, [103pd]-di-acetyl-bis (n4-methylthiosemicarbazone) ([103pd] atsm2) was prepared according to the analogy of radio copper homologues. materials and methods: palladium-103 (t1/2=16.96 d) was produced via the 103rh (p,n) 103pd nuclear reaction with proton energy 18 mev. the final activity was eluted in form of pd (nh4)2cl2 in order to react with bis-thiosemicarbazones to yield [103pd]-labeled compounds. chemical purity of the final product was confirmed to be below the accepted limits by polarography. the labeled compound was purified by reverse phase column chromatography using c18 plus sep-pak. the partition co-efficient of the final complexes were determined. the initial physico-chemical properties of the labeled compounds were compared to those of their copper homologues. results: radiochemical purity of more than 99% using rtlc was obtained (specific activity of about 12500-13000 ci/mol). the stability of the tracer was checked in final product and human serum, at 37c up to 48h. conclusion: the labeled compound prepared in this study is probably one of the few new 103pd-radiolabeled compounds which have a potential for future biological studies, regarding its suitable physicochemical stability.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Radiosynthesis of [103Pd]-di-actyl-bis (N4-methylthiosemicarbazone): a potential therapeutic agent

Background: Due to interesting tumor imaging properties of bis-thiosemicarbazones, [103Pd]-di-acetyl-bis (N4-methylthiosemicarbazone) ([103Pd] ATSM2) was prepared according to the analogy of radio copper homologues. Materials and Methods: Palladium-103 (T1/2=16.96 d) was produced via the 103Rh (p,n) 103Pd nuclear reaction with proton energy 18 MeV. The final activity was eluted in form of Pd ...

متن کامل

Copper-64-diacetyl-bis(N4-methylthiosemicarbazone): An agent for radiotherapy.

Systemic administration of hypoxia-selective (64)Cu-diacetyl-bis(N(4)-methylthiosemicarbazone) ((64)Cu-ATSM) has increased significantly the survival time of hamsters bearing human GW39 colon cancer tumors. Radiotherapy experiments were performed in animals bearing either 7-day-old (0.5-1.0 g) or 15-day-old (1.5-2.0 g) tumors. Studies compared animals treated with a single dose of 0, 4, 6, 7, 8...

متن کامل

Preparation of [64Cu] Pyruvaldehyde-bis (N4-methylthiosemicarbazone) complex as a PET and/or therapeutic radiopharmaceutical

Background: Copper-64 (T1/2=12.7 h) is an important radionuclide used both in PET imaging and therapy. [64Cu]-pyruvaldehyde-bis (N4-methylthiosemicarbazone) ([64Cu]-PTSM) is one of the most famous copper radiopharmaceuticals with unique specifications (suitable half life, stability, etc.). The wide range of 64Cu applications arouse great interest for its production. Materials and Methods: Cu-64...

متن کامل

Intertumoral differences in hypoxia selectivity of the PET imaging agent 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone).

UNLABELLED Cu-Diacetyl-bis(N(4)-methylthiosemicarbazone) (Cu-ATSM) is a recently developed PET imaging agent for tumor hypoxia. However, its accuracy and reliability for measuring hypoxia have not been fully characterized in vivo. The aim of this study was to evaluate (64)Cu-ATSM as a hypoxia PET marker by comparing autoradiographic distributions of (64)Cu-ATSM with a well-established hypoxia m...

متن کامل

preparation of [64cu] pyruvaldehyde-bis (n4-methylthiosemicarbazone) complex as a pet and/or therapeutic radiopharmaceutical

background: copper-64 (t1/2=12.7 h) is an important radionuclide used both in pet imaging and therapy. [64cu]-pyruvaldehyde-bis (n4-methylthiosemicarbazone) ([64cu]-ptsm) is one of the most famous copper radiopharmaceuticals with unique specifications (suitable half life, stability, etc.). the wide range of 64cu applications arouse great interest for its production. materials and methods: cu-64...

متن کامل

Biodistribution of [64Cu]pyruvaldehyde-bis (N4-methylthiosemicarbazone) complex in fibrosarcoma-bearing rats [Persian]

Introduction: 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (64Cu-PTSM)‍ is one of the most important copper radiopharmaceuticals used in clinical experiments. Methods: In this work, copper-64 (T1/2=12.33 h) production has been presented followed by the synthesis of the complexing agent, PTSM, and its structure was confirmed by common spectroscopic methods followed by radiolabeling w...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of radiation research

جلد ۴، شماره ۱، صفحات ۴۱-۴۸

کلمات کلیدی
[ ' p a l l a d i u m ' , 1 0 3 , ' r a d i o l a b e l i n g ' , ' b i s ' , ' t h i o s e m i c a r b a z o n o c o m p l e x e s ' , ' a t s m 2 ' , ' c y c l o t r o n ' ]

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023